I just installed 3ds Max 2012 and of course that uses .NET framework 4, so i run OMSI now and it's reset itself to default settings, not the current ones i had on, the roads and buses are missing when you load them up in the depot. I'm gonna see about reverting back to .NET 3.5 but if future applications require .NET 4, omsi will have to take a backseat as it's so old it cant run on new framework.
Woe, another load of problems with this game, moving on seems to be the only option.